Diabetologia. 2025 Apr 2. doi: 10.1007/s00125-025-06396-5. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Cardiometabolic traits are heritable, and some display parent-of-origin effects, which indicates preferential inheritance from one parent or parental bias. Most studies of these phenomena have f
Diabetologia. 2025 Mar 31. doi: 10.1007/s00125-025-06407-5. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Our aim was to detect early structural and functional changes in the macular capillaries using optical coherence tomography angiography during the course of type 1 or 2 diabetes mellitus.METHOD
Diabetologia. 2025 Mar 29. doi: 10.1007/s00125-025-06413-7. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Type 2 diabetes is a chronic metabolic disorder characterised by insulin resistance and sustained hyperglycaemia, and is a major cause of blindness, kidney failure, heart attacks and stroke. Ou
Diabetologia. 2025 Mar 26. doi: 10.1007/s00125-025-06411-9. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Diabetes is associated with the dysfunction of glucagon-producing pancreatic islet alpha cells, although the underlying mechanisms regulating glucagon secretion and alpha cell dysfunction remai
Diabetologia. 2025 Mar 25. doi: 10.1007/s00125-025-06409-3. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Diabetes is a global health burden characterised by incremental beta cell loss. Islet transplantation is a recognised treatment for individuals with type 1 diabetes and hypoglycaemia unawarenes
Diabetologia. 2025 Mar 25. doi: 10.1007/s00125-025-06412-8. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Diabetic retinopathy features damage to the retinal microvasculature that causes vessels to leak and proliferate and can lead to vision loss and blindness. Inflammation contributes to the devel
No abstractDiabetologia. 2025 Mar 25. doi: 10.1007/s00125-025-06415-5. Online ahead of print.NO ABSTRACTPMID:40131421 | DOI:10.1007/s00125-025-06415-5
No abstractDiabetologia. 2025 Mar 25. doi: 10.1007/s00125-025-06416-4. Online ahead of print.NO ABSTRACTPMID:40131420 | DOI:10.1007/s00125-025-06416-4
Diabetologia. 2025 Mar 22. doi: 10.1007/s00125-025-06402-w. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Weight loss can improve glycaemic management in individuals with type 2 diabetes, but its long-term effects on remission, cardiovascular risk factors and complications remain unclear. We invest
Diabetologia. 2025 Mar 19. doi: 10.1007/s00125-025-06408-4. Online ahead of print.ABSTRACTEarly detection of type 1 diabetes, in its presymptomatic stage, offers significant clinical advantages, including treatment that can delay disease onset. Current screening focuses on identifying islet autoanti
Diabetologia. 2025 Mar 18. doi: 10.1007/s00125-025-06397-4. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: MiRNAs regulate gene expression, influencing beta cell function and pathways. Isoforms of miRNA (isomiRs), sequence variants of miRNAs with post-transcriptional modifications, exhibit cell-type
Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06359-w. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: The nPOD-Virus group collaboratively applied innovative technologies to detect and sequence viral RNA in pancreas and other tissues from organ donors with type 1 diabetes. These analyses involv
Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06384-9. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Earlier studies of pancreases from donors with type 1 diabetes demonstrated enteroviral capsid protein VP1 in beta cells. In the context of a multidisciplinary approach undertaken by the nPOD-V
Diabetologia. 2025 Mar 17. doi: 10.1007/s00125-025-06401-x. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Previous pathology studies have associated enterovirus infections with type 1 diabetes by examining the enterovirus capsid protein 1 (VP1) in autopsy pancreases obtained near diabetes diagnosis
Diabetologia. 2025 Mar 15. doi: 10.1007/s00125-025-06403-9. Online ahead of print.ABSTRACTDiabetes is a rapidly growing global health concern projected to affect one in eight adults by 2045, which translates to roughly 783 million people. The profound metabolic alterations often present in dysglycae
Diabetologia. 2025 Mar 12. doi: 10.1007/s00125-025-06398-3. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Signalling pathways that regulate endothelial cell (EC) dysfunction, ischaemia and inflammation play a crucial role in retinal microangiopathy such as diabetic retinopathy. MAP4K4 is highly exp
Diabetologia. 2025 Mar 12. doi: 10.1007/s00125-025-06379-6. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Biennial, as opposed to annual, screening for diabetic retinopathy was recently introduced within England for those considered to be at 'low risk'. This study aims to examine the impact that an
Diabetologia. 2025 Mar 12. doi: 10.1007/s00125-025-06392-9. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Fat deposition in the pancreas is implicated in beta cell dysfunction and the progress of type 2 diabetes. However, there is limited evidence to confirm the correlation and explore how pancreat
Diabetologia. 2025 Mar 10. doi: 10.1007/s00125-025-06381-y. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: An intronic variant (rs10830963) in MTNR1B (encoding the melatonin receptor type 2 [MT2]) has been shown to strongly associate with impaired glucose regulation and elevated type 2 diabetes prev
Diabetologia. 2025 Mar 10. doi: 10.1007/s00125-025-06393-8. Online ahead of print.ABSTRACTThe accumulation of acquired somatic mutations is a natural consequence of ageing, but the pathophysiological implications of these mutations beyond cancer are only beginning to be understood. Most somatic muta
No abstractDiabetologia. 2025 Mar 10. doi: 10.1007/s00125-025-06404-8. Online ahead of print.NO ABSTRACTPMID:40063268 | DOI:10.1007/s00125-025-06404-8
Diabetologia. 2025 Mar 7. doi: 10.1007/s00125-025-06399-2. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Diabetic peripheral neuropathy is a debilitating microvascular complication of diabetes mellitus, with limited disease-modifying therapies to date. This study aimed to assess the effect of metfo
Diabetologia. 2025 Mar 1. doi: 10.1007/s00125-025-06395-6. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Glycaemic traits such as high fasting glucose levels and insulin resistance are positively associated with the risk of type 2 diabetes and other cardiometabolic diseases. Genetic association stu
Diabetologia. 2025 Feb 28. doi: 10.1007/s00125-025-06394-7. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: While investigating markers for declining beta cell function in type 1 diabetes, we previously demonstrated 11 statistically significant protein associations with fasting C-peptide/glucose rati
