Antioxid Redox Signal. 2024 Dec 24. doi: 10.1089/ars.2024.0653. Online ahead of print.ABSTRACTAims: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, and podocyte injury is one of the major contributors to DKD. As a crucial transcriptional factor that regulates cellular
Ann Med. 2025 Dec;57(1):2445181. doi: 10.1080/07853890.2024.2445181. Epub 2024 Dec 26.ABSTRACTOBJECTIVES: To explore the effect and the probable mechanisms of JLD in the treatment of type 2 diabetes mellitus (T2DM) - associated cognitive impairment (TDACI).METHODS: The effect of JLD in combating TDA
Diabetes Obes Metab. 2024 Dec 26. doi: 10.1111/dom.16146. Online ahead of print.ABSTRACTObesity and type 2 diabetes are significant public health challenges that greatly impact global well-being. The development of effective therapeutic strategies has become more and more concentrated on the central
Diabetes Obes Metab. 2024 Dec 26. doi: 10.1111/dom.16145. Online ahead of print.ABSTRACTAIM: We aimed to identify the characteristics of patients with diabetes who can derive cognitive benefits from intensive blood pressure (BP) treatment using machine learning methods.MATERIALS AND METHODS: Using d
Front Cell Dev Biol. 2024 Dec 11;12:1505601. doi: 10.3389/fcell.2024.1505601. eCollection 2024.ABSTRACTKidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), pose a significant global health challenge, with high morbidity and mortality rates driven by rising prevalenc
Food Sci Nutr. 2024 Nov 26;12(12):10800-10815. doi: 10.1002/fsn3.4617. eCollection 2024 Dec.ABSTRACTRecent research indicates that the activation of the NLRP3 inflammasome is crucial in the development of diabetic kidney disease (DKD). Epigallocatechin-3-gallate (EGCG), the predominant catechin in g
Med Cannabis Cannabinoids. 2024 Nov 14;8(1):1-14. doi: 10.1159/000542511. eCollection 2025 Jan-Dec.ABSTRACTINTRODUCTION: Diabetic peripheral neuropathy (DPN) represents a prevalent neurological complication affecting millions of patients globally. This clinical investigation evaluated the therapeuti
Front Neurol. 2024 Dec 10;15:1462240. doi: 10.3389/fneur.2024.1462240. eCollection 2024.ABSTRACTParkinson's disease (PD) is a chronic, progressive neurological disorder primarily affecting motor control, clinically characterized by resting tremor, bradykinesia, rigidity, and other symptoms that sign
J Transl Med. 2024 Dec 24;22(1):1146. doi: 10.1186/s12967-024-05856-7.ABSTRACTBACKGROUND: Diabetic retinopathy (DR) is the most important complication of Type 2 Diabetes (T2D) in eyes. Despite its prevalence, the early detection and management of DR continue to pose considerable challenges. Our rese
BMJ Open Diabetes Res Care. 2024 Dec 24;12(6):e004506. doi: 10.1136/bmjdrc-2024-004506.ABSTRACTINTRODUCTION: Lifestyle determinants of 2-hour glucose concentration in people with type 2 diabetes and interindividual differences need to be identified.RESEARCH DESIGN AND METHODS: 38 participants with t
ACS Appl Bio Mater. 2024 Dec 24. doi: 10.1021/acsabm.4c01426. Online ahead of print.ABSTRACTGlucose-dependent insulin delivery systems have been recognized as a promising approach for controlling blood sugar levels in individuals with diabetes mellitus (DM). Recently, titanium dioxide nanoparticles
Mol Med Rep. 2025 Mar;31(3):59. doi: 10.3892/mmr.2024.13424. Epub 2024 Dec 24.ABSTRACTThe incidence of hyperuricemia has increased recently, posing a serious threat to public health. Hyperuricemia is associated with an increased risk of gout, chronic kidney disease (CKD), obesity, metabolic syndrome
J Nanobiotechnology. 2024 Dec 23;22(1):792. doi: 10.1186/s12951-024-03072-5.ABSTRACTIslet transplantation is a promising therapy for diabetes, yet the limited survival and functionality of transplanted islet grafts hinder optimal outcomes. Glucagon-like peptide-1 (GLP-1), an endogenous hormone, has
AIDS. 2024 Dec 1;38(15):2100-2103. doi: 10.1097/QAD.0000000000004026. Epub 2024 Nov 14.ABSTRACTPeople with HIV (PWH) and people with diabetes mellitus have increased risk of severe COVID-19, but little is known about humoral response to COVID-19 vaccines in PWH with DM. We investigated SARS-CoV-2 an
J Pharm Technol. 2024 Dec 19:87551225241302731. doi: 10.1177/87551225241302731. Online ahead of print.ABSTRACTBackground: Expansion of sodium-glucose cotransporter-2 inhibitor (SGLT2i) use in chronic kidney disease (CKD) prompted a pragmatic study of their safety and effectiveness in patients with t
J Exp Pharmacol. 2024 Dec 17;16:455-466. doi: 10.2147/JEP.S492971. eCollection 2024.ABSTRACTPURPOSE: Endoplasmic reticulum (ER) stress has a prominent role in the pathogenesis of high-fat diet-induced non-alcohol related fatty liver disease (NAFLD). The aim of this study is to investigate the effect
Biomater Sci. 2024 Dec 23. doi: 10.1039/d4bm01356e. Online ahead of print.ABSTRACTEpigallocatechin gallate (EGCG), an important active component extracted from green tea, has attracted much attention due to its multiple biological activities such as antioxidant, antibacterial, anti-inflammatory, and
Diabetol Metab Syndr. 2024 Dec 23;16(1):309. doi: 10.1186/s13098-024-01557-9.ABSTRACTBACKGROUND: Growing evidence suggests a link between systemic lipopolysaccharide (LPS) exposure and worsening diabetic retinopathy (DR). This study aims to investigate DR's pathogenesis by analyzing LPS-related gene
Biomed Pharmacother. 2024 Dec 21;182:117771. doi: 10.1016/j.biopha.2024.117771. Online ahead of print.ABSTRACTMild cognitive impairment is increasingly recognized as a complication of type 2 diabetes (T2D). Although currently no disease-modifying treatments for cognitive disorders exist, interest su
J Stomatol Oral Maxillofac Surg. 2024 Dec 19:102206. doi: 10.1016/j.jormas.2024.102206. Online ahead of print.ABSTRACTOBJECTIVE: This expert opinion presents provisional guidelines for addressing complications associated with Additively Manufactured Subperiosteal Jaw Implants (AMSJI®) in patients wi
Int J Biol Macromol. 2024 Dec 19:139017. doi: 10.1016/j.ijbiomac.2024.139017. Online ahead of print.ABSTRACTDiabetic Retinopathy (DR) is a significant and progressive eye complication associated with diabetes mellitus, leading to potential vision loss. The pathophysiology of DR involves complex neur
Bioorg Chem. 2024 Dec 17;154:108075. doi: 10.1016/j.bioorg.2024.108075. Online ahead of print.ABSTRACTComplex diseases involve multifaceted etiological components, which limit the effectiveness of conventional targeted therapies. Therefore, standard medicinal treatments often face significant challe
J Cardiothorac Surg. 2024 Dec 20;19(1):672. doi: 10.1186/s13019-024-03157-0.ABSTRACTBACKGROUND: The classification of major adverse cardiovascular event (MACE) endpoints in patients with type 2 diabetes mellitus (T2DM) and either confirmed coronary artery disease (CAD) or high CAD risk, as well as t
Adv Wound Care (New Rochelle). 2024 Dec 20. doi: 10.1089/wound.2024.0075. Online ahead of print.ABSTRACTObjective: Diabetes and smoking are frequently co-morbid conditions leading to arterial insufficiency, significantly increasing the risk of non-healing wounds and subsequent major amputation. Auto
