Clin Med (Lond). 2025 Mar;25(2):100298. doi: 10.1016/j.clinme.2025.100298. Epub 2025 Feb 22.ABSTRACTThe prevalence of type 2 diabetes mellitus (T2DM) and obesity is increasing in young adults, posing significant risks around pregnancy. Obesity also impacts on fertility and the co-existence of polycy
Clin Med (Lond). 2025 Jan;25(1):100275. doi: 10.1016/j.clinme.2024.100275. Epub 2024 Dec 17.ABSTRACTWith a rising worldwide incidence of obesity, particularly in the young, bariatric surgery offers an effective method of meaningful and sustained weight loss. At present, most bariatric procedures are
Clin Med (Lond). 2025 Jan;25(1):100262. doi: 10.1016/j.clinme.2024.100262. Epub 2024 Nov 9.ABSTRACTBACKGROUND: Diabetic ketoacidosis (DKA) and hyperglycaemic hyperosmolar syndrome (HHS) are life-threatening complications of diabetes mellitus. However, limited data about DKA and HHS are available in
Clin Med (Lond). 2024 Nov;24(6):100255. doi: 10.1016/j.clinme.2024.100255. Epub 2024 Oct 19.ABSTRACTThere are significant variations in discharge post-diabetes-related ketoacidosis (DKA) hospitalisation, yet there is a paucity of research to understand or minimise the reasons. This quality improveme
Clin Med (Lond). 2024 Nov;24(6):100249. doi: 10.1016/j.clinme.2024.100249. Epub 2024 Oct 4.ABSTRACTBACKGROUND: Corticosteroids raise blood glucose concentrations; however, it remains unknown which form of administration, oral or intravenous, is associated with the greatest degree of blood glucose ri
Clin Med (Lond). 2024 Jul;24(4):100223. doi: 10.1016/j.clinme.2024.100223. Epub 2024 Jun 12.ABSTRACTThe gap in excess mortality between patients with and without diabetes has not decreased over time. The aim of this study was to investigate the determinants of mortality after acute myocardial infarc
Clin Med (Lond). 2024 May;24(3):100206. doi: 10.1016/j.clinme.2024.100206. Epub 2024 Apr 21.ABSTRACTObesity affects one in four people in the United Kingdom and costs the National Health Service (NHS) ∼£6.5 billion annually. The glucagon-like peptide-1 (GLP-1) receptor analogues, such as once-daily
Clin Med (Lond). 2024 Mar;24(2):100033. doi: 10.1016/j.clinme.2024.100033. Epub 2024 Mar 20.ABSTRACTA 34-year-old woman was diagnosed with type 1 diabetes mellitus and treated with insulin for 24 years. The patient has a family history of diabetes in three consecutive generations. Her Whole exon seq
Clin Med (Lond). 2024 Mar;24(2):100029. doi: 10.1016/j.clinme.2024.100029. Epub 2024 Feb 20.ABSTRACTINTRODUCTION: The community deintensification rates in older people with diabetes are low and hospital admission presents an opportunity for medication review. We audited the inpatient assessment and
Clin Med (Lond). 2024 Mar;24(2):100031. doi: 10.1016/j.clinme.2024.100031. Epub 2024 Feb 16.ABSTRACTDiabetic retinopathy and nephropathy share pathophysiological mechanisms and there is a defined correlation between the severity of both these microvascular complications from suboptimal glycaemic con
No abstractClin Med (Lond). 2024 Jan;24(1):100023. doi: 10.1016/j.clinme.2024.100023. Epub 2024 Feb 7.NO ABSTRACTPMID:38331387 | PMC:PMC11024838 | DOI:10.1016/j.clinme.2024.100023
No abstractClin Med (Lond). 2024 Jan;24(1):100021. doi: 10.1016/j.clinme.2024.100021. Epub 2024 Jan 28.NO ABSTRACTPMID:38290693 | PMC:PMC11023003 | DOI:10.1016/j.clinme.2024.100021
No abstractClin Med (Lond). 2023 Nov;23(Suppl 6):71. doi: 10.7861/clinmed.23-6-s71.NO ABSTRACTPMID:38182193 | PMC:PMC11046661 | DOI:10.7861/clinmed.23-6-s71
No abstractClin Med (Lond). 2023 Nov;23(Suppl 6):30. doi: 10.7861/clinmed.23-6-s30.NO ABSTRACTPMID:38182179 | PMC:PMC11046614 | DOI:10.7861/clinmed.23-6-s30
Clin Med (Lond). 2023 Nov;23(6):588-593. doi: 10.7861/clinmed.2023-0185.ABSTRACTThere is cumulative evidence that pancreatic exocrine insufficiency (PEI) is under-recognised and can occur in patients with 'at-risk' conditions. Thus, we aimed to assess the current practice and yield of requesting fae
Clin Med (Lond). 2023 Jul;23(4):353-356. doi: 10.7861/clinmed.2023-0195.ABSTRACTObesity and chronic kidney disease (CKD) are common and frequently coexisting medical conditions. Already well known to be a risk factor for type 2 diabetes mellitus (T2DM), ischaemic heart disease, stroke, hypertension,
Clin Med (Lond). 2023 Jul;23(4):323-329. doi: 10.7861/clinmed.2023-0183.ABSTRACTObesity is a global epidemic that has worsened over the past few decades. It is strongly associated with multiple health conditions, including type 2 diabetes mellitus, cardiovascular diseases, obstructive sleep apnoea,
Clin Med (Lond). 2023 Jul;23(4):380-386. doi: 10.7861/clinmed.2022-0442.ABSTRACTOBJECTIVE: The objective of this study was to assess whether poor sleep is independently associated with cardiovascular disease in people with type 2 diabetes mellitus (T2DM).METHODS: A cross-sectional study was performe
Clin Med (Lond). 2023 Jul;23(4):337-346. doi: 10.7861/clinmed.2023-0144.ABSTRACTObesity is a chronic disease associated with increased morbidity and mortality. Bariatric surgery can lead to sustained long-term weight loss (WL) and improvement in multiple obesity-related complications, but it is not
Clin Med (Lond). 2023 Jul;23(4):304-310. doi: 10.7861/clinmed.2023-0157.ABSTRACTObesity is a multifaceted and complex condition that requires holistic management. It currently affects nearly one in four adults in the UK, with the UK ranked 10th globally for the highest obesity rates. Obesity is proj
Clin Med (Lond). 2023 Jul;23(4):364-371. doi: 10.7861/clinmed.2023-0135.ABSTRACTDiabetes and obesity are closely interlinked. Obesity is a major risk factor for the development of type 2 diabetes mellitus and appears to be an important risk factor for diabetic micro- and macrovascular complications.
Clin Med (Lond). 2023 May;23(3):271-274. doi: 10.7861/clinmed.2023-0137.ABSTRACTA 63-year-old man developed reduced consciousness and dysphagia progressively. Examination and parameters were normal, except for a Glasgow Coma Scale score of seven, and his grading on the swallow water test increased f
Clin Med (Lond). 2023 May;23(3):254-258. doi: 10.7861/clinmed.2023-RM1.ABSTRACTChronic kidney disease (CKD) represents an enormous healthcare burden, the management of which has been stagnant for the last couple of decades, with blockade of the renin-angiotensin-aldosterone system (RAAS) the most po
Clin Med (Lond). 2023 May;23(3):228-233. doi: 10.7861/clinmed2022-0489. Epub 2023 May 17.ABSTRACTThe term 'diabetic foot disease' (DFD) often signifies the presence of foot ulceration and infection, but one must also be wary of the rarer occurrence of Charcot foot disease. The worldwide prevalence o
