Xing Liu il 26/12/2024

Nuclear Factor Erythroid 2-Related Factor 2 Activator DDO-1039 Ameliorates Podocyte Injury in Diabetic Kidney Disease via Suppressing Oxidative Stress, Inflammation, and Ferroptosis

Antioxid Redox Signal. 2024 Dec 24. doi: 10.1089/ars.2024.0653. Online ahead of print.ABSTRACTAims: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, and podocyte injury is one of the major contributors to DKD. As a crucial transcriptional factor that regulates cellular

Haiyan Gu il 26/12/2024

Exploring the effect and mechanism of action of Jinlida granules (JLD) in the treatment of diabetes-associated cognitive impairment based on network pharmacology with experimental validation

Ann Med. 2025 Dec;57(1):2445181. doi: 10.1080/07853890.2024.2445181. Epub 2024 Dec 26.ABSTRACTOBJECTIVES: To explore the effect and the probable mechanisms of JLD in the treatment of type 2 diabetes mellitus (T2DM) - associated cognitive impairment (TDACI).METHODS: The effect of JLD in combating TDA

Sergiu Iordache il 26/12/2024

Predictive Factors for Cut-Out Risks of Unstable Trochanteric Fractures

Cureus. 2024 Nov 24;16(11):e74355. doi: 10.7759/cureus.74355. eCollection 2024 Nov.ABSTRACTFractures of the trochanteric mass represent a significant proportion of hip fractures. These fractures often occur in the elderly due to compromised bone quality, leading to a high predisposition for instabil

Farhan Khan il 26/12/2024

Comparing the Efficacy and Long-Term Outcomes of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors, Dipeptidyl Peptidase-4 (DPP-4) Inhibitors, Metformin, and Insulin in the Management of Type 2 Diabetes Mellitus

Cureus. 2024 Nov 25;16(11):e74400. doi: 10.7759/cureus.74400. eCollection 2024 Nov.ABSTRACTType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance, and decreased insulin secretion. With its rising global prevalence, effective management stra

Eram A Mahaldar il 26/12/2024

Insulinoma: Unraveling the Mystery of a Stealthy Culprit

Cureus. 2024 Nov 24;16(11):e74364. doi: 10.7759/cureus.74364. eCollection 2024 Nov.ABSTRACTInsulinoma, a rare pancreatic neuroendocrine tumor, stealthily lurks within the pancreas, often evading detection until its distinctive symptom, recurrent hypoglycemia, comes to the surface. This case report a

Amankeldi A Salybekov il 26/12/2024

Cell therapy in kidney diseases: advancing treatments for renal regeneration

Front Cell Dev Biol. 2024 Dec 11;12:1505601. doi: 10.3389/fcell.2024.1505601. eCollection 2024.ABSTRACTKidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), pose a significant global health challenge, with high morbidity and mortality rates driven by rising prevalenc

Xinlu Li il 26/12/2024

Multi-omics in exploring the pathophysiology of diabetic retinopathy

Front Cell Dev Biol. 2024 Dec 11;12:1500474. doi: 10.3389/fcell.2024.1500474. eCollection 2024.ABSTRACTDiabetic retinopathy (DR) is a leading global cause of vision impairment, with its prevalence increasing alongside the rising rates of diabetes mellitus (DM). Despite the retina's complex structure

Shilin Zhong il 26/12/2024

Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and their correlations with BMI: a nested cohort study in China

Front Microbiol. 2024 Dec 11;15:1467414. doi: 10.3389/fmicb.2024.1467414. eCollection 2024.ABSTRACTINTRODUCTION: Gut microbiota (GM) has been implicated in gestational diabetes mellitus (GDM), yet longitudinal changes across trimesters remain insufficiently explored.METHODS: This nested cohort study