Taka-Aki Sakaue il 01/04/2025

Immune checkpoint inhibitor-related type 1 diabetes mellitus with closely monitored dynamics of glutamic acid decarboxylase antibody levels before and after disease onset

Diabetol Int. 2025 Feb 10;16(2):427-431. doi: 10.1007/s13340-025-00795-0. eCollection 2025 Apr.ABSTRACTImmune checkpoint inhibitor (ICI)-related type 1 diabetes mellitus (T1DM) is a severe immune-related adverse event (irAE), occurring in < 1% of cases. ICI-related T1DM typically progresses more rap

Xiaoli Qu il 01/04/2025

Global Burden of Type 1 Diabetes Mellitus Related Chronic Kidney Disease among Adolescents and Young Adults, and Projections to 2035: Results from the Global Burden of Disease Study 2021

Diabetes Metab J. 2025 Mar 10. doi: 10.4093/dmj.2024.0544. Online ahead of print.ABSTRACTBACKGROUND: Type 1 diabetes mellitus related chronic kidney disease (T1DM-CKD) presents a global health challenge, with unclear trends and patterns among adolescents and young adults. This study analyzed the bur

Ruiling Zhao il 01/04/2025

Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-cell subpopulations

BMC Med. 2025 Mar 31;23(1):189. doi: 10.1186/s12916-025-04001-5.ABSTRACTBACKGROUND: Antigen-specific immunotherapy shows potential for inducing long-term immune tolerance in type 1 diabetes (T1D), yet its clinical application is hampered by uncertainty regarding dominant epitopes. Conversely, non-an