Ann Med. 2025 Dec;57(1):2445181. doi: 10.1080/07853890.2024.2445181. Epub 2024 Dec 26.ABSTRACTOBJECTIVES: To explore the effect and the probable mechanisms of JLD in the treatment of type 2 diabetes mellitus (T2DM) - associated cognitive impairment (TDACI).METHODS: The effect of JLD in combating TDA
Cureus. 2024 Nov 25;16(11):e74400. doi: 10.7759/cureus.74400. eCollection 2024 Nov.ABSTRACTType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance, and decreased insulin secretion. With its rising global prevalence, effective management stra
Front Pharmacol. 2024 Dec 11;15:1506437. doi: 10.3389/fphar.2024.1506437. eCollection 2024.ABSTRACTBACKGROUND AND OBJECTIVE: Dental implant therapy faces challenges in patients with Type 1 and Type 2 Diabetes Mellitus (T1DM and T2DM) due to adverse effects on bone metabolism and immune response. Des
Front Immunol. 2024 Dec 11;15:1488220. doi: 10.3389/fimmu.2024.1488220. eCollection 2024.ABSTRACTBACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) and the thyrotropin receptor (TSH-R) are expressed on orbital cells and thyrocytes. These receptors are targeted in autoimmune-induced thyro
J Family Med Prim Care. 2024 Nov;13(11):5033-5039. doi: 10.4103/jfmpc.jfmpc_747_24. Epub 2024 Nov 18.ABSTRACTBACKGROUND: Diabetes mellitus (DM) affects a substantial proportion of the world's population and is associated with an increased risk of sudden cardiac death (SCD) due to cardiac arrhythmias
Front Endocrinol (Lausanne). 2024 Dec 11;15:1439705. doi: 10.3389/fendo.2024.1439705. eCollection 2024.ABSTRACTBACKGROUND: Although immune checkpoint inhibitors (ICIs) are effective cancer drugs, ICI-induced diabetes is a rare but a life-threatening adverse event for patients. The deleterious action
Curr Protein Pept Sci. 2024 Dec 24. doi: 10.2174/0113892037324425241018061548. Online ahead of print.ABSTRACTTLR4 stands at the forefront of innate immune responses, recognizing various pathogen- associated molecular patterns and endogenous ligands, thus serving as a pivotal mediator in the immune s
Intern Med. 2024 Dec 26. doi: 10.2169/internalmedicine.4648-24. Online ahead of print.ABSTRACTThere are no clear strategies for non-insulin-dependent slowly progressive type 1 diabetes mellitus (SPIDDM). We herein report a 25-year-old man with SPIDDM in whom appropriate diet therapy and exercise imp
Cell Physiol Biochem. 2024 Nov 28;58(6):702-721. doi: 10.33594/000000744.ABSTRACTBACKGROUND/AIMS: Gestational Diabetes Mellitus (GDM), a prevalent complication in pregnancy, is characterized by the Diabetes Association as diabetes diagnosed in the second or third trimester, often remaining asymptoma
Front Pharmacol. 2024 Dec 10;15:1507860. doi: 10.3389/fphar.2024.1507860. eCollection 2024.ABSTRACTAge-related macular degeneration (AMD) is a leading cause of blindness among the elderly worldwide. Anti-vascular endothelial growth factor (anti-VEGF) injections remain the first-line therapy for AMD.
Mol Ther Oncol. 2024 Nov 23;32(4):200908. doi: 10.1016/j.omton.2024.200908. eCollection 2024 Dec 19.ABSTRACTPatients with osteosarcoma (OS), a debilitating pediatric bone malignancy, have limited treatment options to combat aggressive disease. OS thrives on insulin growth factor (IGF)-mediated signa
J Diabetes Res. 2024 Dec 17;2024:7557153. doi: 10.1155/jdr/7557153. eCollection 2024.ABSTRACTBackground: Young-onset diabetes (YOD) is characterised by unique diagnostic and management challenges more pronounced in resource-limited settings like Sri Lanka. Aims: We aimed to ascertain the prevalence,
Front Endocrinol (Lausanne). 2024 Dec 10;15:1481270. doi: 10.3389/fendo.2024.1481270. eCollection 2024.ABSTRACTType 2 diabetes mellitus (T2DM) is a chronic metabolic disease caused by insulin resistance (IR) and insufficient insulin secretion. Its characteristic pathophysiological processes involve
J Biomed Mater Res A. 2025 Jan;113(1):e37854. doi: 10.1002/jbm.a.37854.ABSTRACTPrecise blood glucose control continues to be a critical challenge in the treatment and management of type 1 diabetes in order to mitigate both acute and chronic complications. This study investigates the development of a
Am J Perinatol. 2024 Dec 24. doi: 10.1055/a-2490-3118. Online ahead of print.ABSTRACTThe Diabetes in Pregnancy Program Project Grant (PPG) was a 15-year program focused on enhancing the care for women with insulin-dependent diabetes mellitus (IDDM) during pregnancy and improving the well-being of th
Horm Res Paediatr. 2024 Dec 24:1-8. doi: 10.1159/000543329. Online ahead of print.ABSTRACTINTRODUCTION: Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare but severe complication of hyperthyroidism characterized by acute muscle weakness. This study reports the first case of THPP in an adoles
Endocrinol Diabetes Metab. 2025 Jan;8(1):e70020. doi: 10.1002/edm2.70020.ABSTRACTPURPOSE: To investigate the impact of clinical and socio-economic factors on glycaemic control and construct statistical models to predict optimal glycaemic control (OGC) after implementing intermittently scanned contin
J Diabetes Sci Technol. 2024 Dec 24:19322968241305647. doi: 10.1177/19322968241305647. Online ahead of print.ABSTRACTINTRODUCTION: Two phase 3 randomized controlled studies (ADJUNCT ONE (Clinicaltrials.gov: NCT01836523), ADJUNCT TWO (Clinicaltrials.gov: NCT02098395)) evaluated liraglutide (1.8, 1.2
J Biochem Mol Toxicol. 2025 Jan;39(1):e70098. doi: 10.1002/jbt.70098.ABSTRACTAmong the diabetes-related complications, diabetic nephropathy is the major complication and it leads to end-stage renal failure. In the current investigation, we examined the protection of brucine, an alkaloid extracted fr
Genes Dis. 2024 Sep 10;12(2):101430. doi: 10.1016/j.gendis.2024.101430. eCollection 2025 Mar.ABSTRACTPhosphoinositide 3-kinases (PI3Ks) are heterodimers consisting of a p110 catalytic subunit and a p85 regulatory subunit. The PIK3CA gene, which encodes the p110α, is the most frequently mutated oncog
Risk Manag Healthc Policy. 2024 Dec 19;17:3227-3238. doi: 10.2147/RMHP.S484334. eCollection 2024.ABSTRACTBACKGROUND: The aging global population presents challenges in medication management, particularly among diabetic elderly patients vulnerable to potentially inappropriate medications (PIM). PIM c
Cureus. 2024 Nov 22;16(11):e74272. doi: 10.7759/cureus.74272. eCollection 2024 Nov.ABSTRACTIntraoperative hyperkalemia is particularly common in patients with chronic kidney disease (CKD). We report two cases of intraoperative hyperkalemia occurring under general anesthesia, while potassium levels r
Semin Dial. 2024 Dec 24. doi: 10.1111/sdi.13236. Online ahead of print.ABSTRACTWe report the successful application of single pass albumin dialysis (SPAD) and hemoadsorption (HA) in two teenagers with amlodipine poisoning. A 16-year-old girl with amlodipine overdose developed refractory shock and la
Recent Adv Food Nutr Agric. 2024 Dec 23. doi: 10.2174/012772574X351036241122040415. Online ahead of print.ABSTRACTA metabolic disease that requires insulin and is marked by consistently high blood sugar levels is known as diabetes mellitus. Many healthcare systems throughout the world have long reli
